ADNP

Across TCGA patient cohorts, ADNP mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADNP-associated genes across cancer lineages are MSH2, p53, and TIGAR. Each is linked with ADNP in more than 1 cancer types. Because this analysis shows association rather than direction, both ADNP-to-partner and partner-to-ADNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ADNP-low versus ADNP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADNP→partner) and Y-score (partner→ADNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.265	-1.899	<.001	.004	3	2
UCEC	p53 →	-0.275	-1.584	.014	.017	3	2
UCEC	TIGAR →	+0.107	+1.142	.015	.017	3	2
UCEC	BRD4 →	+0.173	+1.807	.031	.023	3	2
UCEC	14-3-3_beta →	-0.102	-2.558	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.177	-1.321	.015	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MSH2 by ADNP expression — UCEC

Explore this box plot interactively →