ADM

Across TCGA patient cohorts, ADM mutation is significantly associated with the RNA expression of many other genes, with 136 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADM-associated genes across cancer lineages are OR6K6, RNA5SP419, and SNRPGP7. Each is linked with ADM in more than 1 cancer types. Because this analysis shows association rather than direction, both ADM-to-partner and partner-to-ADM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6K6 grouped by ADM-low versus ADM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADM→partner) and Y-score (partner→ADM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6K6 →	+0.104	+3.621	<.001	.004	3	2
UCEC	RNA5SP419 →	+1.092	+3.077	<.001	.005	3	2
COAD	SNRPGP7 →	+0.527	+4.602	<.001	.008	3	2
SKCM	PPIAP5 →	+0.137	+3.533	<.001	.007	3	2
BLCA	MIR4797 →	+0.481	+3.642	.009	.009	3	2
BLCA	KRT8P27 →	+0.032	+5.255	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 136 associations by consensus.

OR6K6 by ADM expression — UCEC

Explore this box plot interactively →