ADM

Across TCGA pan-cancer cohorts, ADM RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ADM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADM RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADM is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ADM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.861	<.001	12	view →
HNSC	Male	All	+1.643	<.001	11	view →
THCA	Female	III,IV	+2.130	<.001	10	view →
UCEC	All	All	+1.896	<.001	8	view →
BRCA	All	III,IV	−1.743	<.001	6	view →
LUSC	Male	All	+1.376	<.001	6	view →
KICH	All	All	+1.209	<.001	5	view →
PAAD	All	All	+2.879	.010	4	view →
COAD	Female	All	−0.594	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ADM–KIRC

Open the KIRC breakdown →