ADM

Across TCGA patient cohorts, ADM mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADM-associated genes across cancer lineages are Ku80, p62 Lck ligand, and PDK1_pS241. Each is linked with ADM in more than 1 cancer types. Because this analysis shows association rather than direction, both ADM-to-partner and partner-to-ADM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ADM-low versus ADM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADM→partner) and Y-score (partner→ADM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.302	+2.820	.037	.036	3	1
UCEC	p62 Lck ligand →	+0.765	+2.817	<.001	.036	3	1
UCEC	PDK1_pS241 →	+0.267	+2.820	.010	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Ku80 by ADM expression — UCEC

Explore this box plot interactively →