ADM

Across TCGA cell cohorts, ADM RNA expression is significantly associated with the go_rna of many other GO terms, with 5,090 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ADM-associated GO terms across cancer lineages are Adrenomedullin receptor signaling pathway, Calcitonin family receptor signaling pathway, and Regulation of progesterone biosynthetic process. Each is linked with ADM in more than 18 cancer types. Because this analysis shows association rather than direction, both ADM-to-partner and partner-to-ADM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adrenomedullin receptor signaling pathway grouped by ADM-low versus ADM-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADM→partner) and Y-score (partner→ADM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Adrenomedullin receptor signaling pathway →	+1.480	+2.868	<.001	<.001	3	19
STOMACH	Calcitonin family receptor signaling pathway →	+1.347	+4.927	<.001	<.001	3	18
LUNG_SCLC	Regulation of progesterone biosynthetic process →	+1.038	+1.999	<.001	.002	3	18
LIVER	Negative regulation of vasoconstriction →	+0.315	+2.944	<.001	<.001	3	14
LIVER	Vascular associated smooth muscle cell development →	+0.268	+2.845	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of vasculogenesis →	+0.195	+3.469	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,090 associations by consensus.

Adrenomedullin receptor signaling pathway by ADM expression — STOMACH

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