ADK

Across TCGA pan-cancer cohorts, ADK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ADK data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ADK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ADK expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

PDAC, COAD, and CCRCC are the cancer types where ADK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.390	0.719	.002	27	view →
COAD	DFS	Median	IV	0.493	0.944	.031	18	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	17	view →
GBM	OS	Quartile	All	0.752	0.261	.007	5	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	4	view →
LSCC	OS	Quartile	All	0.690	0.915	.027	4	view →
UCEC	DFS	Median	All	0.943	0.867	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ADK–PDAC (OS)

Open the PDAC breakdown →