ADIRF-AS1

Across TCGA pan-cancer cohorts, ADIRF-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ADIRF-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ADIRF-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ADIRF-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRP show a favorable association.

UCS, KIRP, and LGG are the cancer types where ADIRF-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.739	0.210	.002	88	view →
KIRP	DFS	Median	II,III,IV	0.842	0.156	<.001	64	view →
LGG	DFS	Median	All	0.309	0.450	<.001	45	view →
UVM	DFS	Tertile	III,IV	0.263	0.857	<.001	37	view →
UCEC	DFS	Tertile	All	0.565	0.844	<.001	36	view →
ESCA	OS	Median	III,IV	0.665	0.433	.015	25	view →
READ	OS	Tertile	III,IV	0.899	0.576	.005	21	view →
KICH	DFS	Median	All	1.000	0.688	.007	19	view →
COAD	DFS	Quartile	All	0.708	0.841	.007	18	view →
SARC	OS	Median	All	0.887	0.786	.005	16	view →
CESC	DFS	Quartile	All	0.893	0.768	.024	14	view →
THCA	DFS	Quartile	II,III,IV	0.819	0.946	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ADIRF-AS1–UCS (OS)

Open the UCS breakdown →