ADIRF-AS1

Across TCGA pan-cancer cohorts, ADIRF-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADIRF-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ADIRF-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADIRF-AS1 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

LUAD, COAD, and HNSC are the cancer types where ADIRF-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADIRF-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.565	<.001	9	view →
COAD	All	II,III,IV	+0.483	<.001	9	view →
HNSC	Male	IV	+1.115	<.001	8	view →
UCEC	All	All	−1.932	<.001	6	view →
BRCA	Female	All	−1.273	<.001	6	view →
CHOL	All	II,III,IV	+1.385	<.001	5	view →
THCA	All	II,III,IV	−0.812	<.001	5	view →
LUSC	Female	All	−1.111	<.001	3	view →
PRAD	All	All	−0.660	<.001	2	view →
READ	All	III,IV	+0.635	.019	2	view →
STAD	All	All	−0.505	.009	2	view →
KIRC	Female	III,IV	+0.384	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADIRF-AS1–LUAD

Open the LUAD breakdown →