ADIG

Across TCGA patient cohorts, ADIG mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible ADIG-associated genes across cancer lineages are RNA5SP403, SNORD115-5, and RNU6-654P. Each is linked with ADIG in more than 1 cancer types. Because this analysis shows association rather than direction, both ADIG-to-partner and partner-to-ADIG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP403 grouped by ADIG-low versus ADIG-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADIG→partner) and Y-score (partner→ADIG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP403 →	+0.318	+7.954	<.001	.008	3	1
HNSC	SNORD115-5 →	+0.393	+7.954	<.001	.008	3	1
HNSC	RNU6-654P →	+0.318	+7.954	<.001	.008	3	1
HNSC	RNU6-463P →	+0.318	+7.954	<.001	.008	3	1
HNSC	RNU6-279P →	+0.333	+7.954	<.001	.008	3	1
UCEC	IGLL4P →	+0.659	+3.408	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RNA5SP403 by ADIG expression — HNSC

Explore this box plot interactively →