ADHFE1

Across TCGA cell cohorts, ADHFE1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADHFE1-associated genes across cancer lineages are AMELX, LYZL2, and ACTRT1. Each is linked with ADHFE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADHFE1-to-partner and partner-to-ADHFE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMELX grouped by ADHFE1-low versus ADHFE1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADHFE1→partner) and Y-score (partner→ADHFE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AMELX →	+0.038	+5.539	<.001	.003	3	2
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
BLOOD_Leukemia	ACTRT1 →	+0.028	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SPPL2C →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	CBLN4 →	+0.006	+5.539	<.001	.003	3	1
SKIN	SIGLEC5 →	+0.014	+4.415	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AMELX by ADHFE1 expression — BLOOD_Leukemia

Explore this box plot interactively →