ADH5P4

Across TCGA pan-cancer cohorts, ADH5P4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ADH5P4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ADH5P4 RNA is repressed in tumor relative to normal tissue. In most cancer types ADH5P4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and HNSC are the cancer types where ADH5P4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADH5P4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.222	<.001	6	view →
KICH	All	All	−0.294	<.001	5	view →
HNSC	All	All	+0.164	.001	5	view →
COAD	All	II,III,IV	+0.368	.014	4	view →
BRCA	Female	II,III,IV	−0.174	<.001	4	view →
KIRP	Male	All	−0.242	.010	2	view →
PAAD	All	All	−0.232	.041	2	view →
LIHC	Male	All	+0.149	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ADH5P4–THCA

Open the THCA breakdown →