Across TCGA patient cohorts, ADH5 mutation is significantly associated with the RNA expression of many other genes, with 898 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH5-associated genes across cancer lineages are ATP6V1G1P7, USP9YP10, and OR1E3. Each is linked with ADH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH5-to-partner and partner-to-ADH5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH5→partner) and Y-score (partner→ADH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	ATP6V1G1P7 →	+0.134	+7.977	<.001	.007	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
HNSC	OR1E3 →	+0.044	+5.182	.001	.007	3	2
HNSC	FAM27E5 →	+0.136	+6.111	<.001	.002	3	2
BRCA	IFNA7 →	+0.075	+6.064	<.001	.002	3	2
BRCA	GLRXP1 →	+0.178	+5.441	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 898 associations by consensus.

Exploration

ADH5 survival (RNA) · tumor vs normal (RNA) · all ADH5 data types