ADGRV1

Across TCGA patient cohorts, ADGRV1 mutation is significantly associated with the RNA expression of many other genes, with 12,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRV1-associated genes across cancer lineages are ACKR1, HSPA9, and CLEC3B. Each is linked with ADGRV1 in more than 8 cancer types. Because this analysis shows association rather than direction, both ADGRV1-to-partner and partner-to-ADGRV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACKR1 grouped by ADGRV1-low versus ADGRV1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRV1→partner) and Y-score (partner→ADGRV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ACKR1 →	-1.294	-1.777	<.001	<.001	3	9
UCEC	HSPA9 →	+0.390	+1.579	<.001	<.001	3	8
LUAD	CLEC3B →	-1.010	-2.502	<.001	.001	3	8
STAD	PAPLN →	-0.838	-3.857	<.001	<.001	3	7
BLCA	AOX1 →	-0.579	-2.159	.001	.002	3	7
LUAD	PRC1 →	+0.989	+1.938	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,579 associations by consensus.

ACKR1 by ADGRV1 expression — BLCA

Explore this box plot interactively →