ADGRV1

Across TCGA patient cohorts, ADGRV1 mutation is significantly associated with the total protein of many other genes, with 144 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ADGRV1-associated genes across cancer lineages are PCNA, Cyclin-B1, and mTOR_pS2448. Each is linked with ADGRV1 in more than 7 cancer types. Because this analysis shows association rather than direction, both ADGRV1-to-partner and partner-to-ADGRV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADGRV1-low versus ADGRV1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRV1→partner) and Y-score (partner→ADGRV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.236	+3.459	.011	.004	3	8
LUAD	Cyclin-B1 →	+0.783	+2.222	<.001	.009	3	7
LUAD	mTOR_pS2448 →	-0.223	-3.321	.001	.009	3	6
LUAD	PDCD4 →	-0.489	-2.568	.001	.001	3	6
STAD	Cyclin-E1 →	+0.461	+2.337	.004	.002	3	6
LUAD	PKC-b-II_pS660 →	-0.582	-2.584	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

PCNA by ADGRV1 expression — STAD

Explore this box plot interactively →