ADGRV1

Across TCGA cell cohorts, ADGRV1 mutation is significantly associated with the RNA expression of many other genes, with 1,911 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRV1-associated genes across cancer lineages are HOXA1, PSAT1, and MTHFD2. Each is linked with ADGRV1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRV1-to-partner and partner-to-ADGRV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXA1 grouped by ADGRV1-low versus ADGRV1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRV1→partner) and Y-score (partner→ADGRV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HOXA1 →	-0.603	-1.896	.003	.001	3	4
BLOOD_Leukemia	PSAT1 →	+1.578	+2.058	.005	.005	3	4
SKIN	MTHFD2 →	+0.622	+1.435	.002	.001	3	4
BREAST	ECI1 →	+0.616	+2.372	<.001	<.001	3	4
LARGE_INTESTINE	TUBE1 →	+0.707	+1.415	.008	.006	3	4
PANCREAS	EPRS1 →	+0.639	+3.226	<.001	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,911 associations by consensus.

HOXA1 by ADGRV1 expression — BLOOD_Leukemia

Explore this box plot interactively →