ADGRL4

Across TCGA cell cohorts, ADGRL4 mutation is significantly associated with the RNA expression of many other genes, with 683 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRL4-associated genes across cancer lineages are DUT, ZNF280D, and RWDD4. Each is linked with ADGRL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRL4-to-partner and partner-to-ADGRL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUT grouped by ADGRL4-low versus ADGRL4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL4→partner) and Y-score (partner→ADGRL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DUT →	+0.523	+2.378	.001	.008	3	2
LUNG_NSCLC_LUAD	ZNF280D →	+0.676	+3.240	<.001	.003	3	2
LUNG_NSCLC_LUAD	RWDD4 →	+0.453	+3.495	.002	.001	3	2
OESOPHAGUS	PPDPFL →	+0.033	+4.906	<.001	.006	3	1
OESOPHAGUS	SCYGR10 →	+0.203	+4.906	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 683 associations by consensus.

DUT by ADGRL4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →