ADGRL3

Across TCGA pan-cancer cohorts, ADGRL3 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated ADGRL3 data layer compared with 27 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ADGRL3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADGRL3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CESC, BRCA, and HNSC are the cancer types where ADGRL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	III,IV	0.195	0.737	<.001	30	view →
BRCA	DFS	Median	All	0.193	0.531	<.001	20	view →
HNSC	OS	Median	IV	1.000	0.346	.014	17	view →
ACC	OS	Median	All	0.273	0.802	.017	15	view →
UCEC	DFS	Median	All	0.928	0.824	.019	14	view →
OV	OS	Median	IV	0.022	0.760	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
SCLC	OS	Median	II,III,IV	0.314	0.627	.005	11	view →
LUSC	OS	Median	IV	0.057	0.786	.017	6	view →
ESCA	DFS	Median	III,IV	0.167	0.453	.013	6	view →
COAD	DFS	Median	IV	0.028	0.496	<.001	6	view →
BLCA	OS	Median	III,IV	0.755	0.342	.019	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

ADGRL3–CESC (DFS)

Open the CESC breakdown →