ADGRL3

Across TCGA pan-cancer cohorts, ADGRL3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADGRL3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ADGRL3 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRL3 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and HNSC are the cancer types where ADGRL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.190	<.001	12	view →
KICH	Male	All	−1.354	<.001	11	view →
HNSC	Male	III,IV	+1.135	<.001	8	view →
KIRC	Male	II,III,IV	−0.551	<.001	8	view →
READ	All	All	−1.172	<.001	7	view →
LUAD	All	II,III,IV	−0.657	<.001	7	view →
BRCA	All	All	−1.316	<.001	6	view →
KIRP	All	All	−0.549	<.001	6	view →
BLCA	All	IV	−0.885	.004	3	view →
THCA	All	III,IV	−0.381	.003	3	view →
PRAD	All	All	−0.567	<.001	2	view →
STAD	All	All	−0.431	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADGRL3–COAD

Open the COAD breakdown →