ADGRL3

Across TCGA pan-cancer cohorts, ADGRL3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ADGRL3 data layer compared with 27 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADGRL3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ADGRL3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where ADGRL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	1.000	0.547	.022	11	view →
PDAC	OS	Median	All	0.730	1.000	.038	5	view →
LSCC	OS	Tertile	All	0.825	0.953	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ADGRL3–HNSC (OS)

Open the HNSC breakdown →