ADGRL3

Across TCGA patient cohorts, ADGRL3 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRL3-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and GAPDH. Each is linked with ADGRL3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRL3-to-partner and partner-to-ADGRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ADGRL3-low versus ADGRL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL3→partner) and Y-score (partner→ADGRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.431	+1.934	<.001	.002	3	5
COAD	Caspase-7-cleavedD198 →	+1.262	+2.923	<.001	<.001	3	4
UCEC	GAPDH →	+0.308	+1.514	.026	.012	3	4
UCEC	Cyclin-E1 →	+0.223	+1.289	.047	.021	3	4
LUAD	Acetyl-a-Tubulin-Lys40 →	-0.437	-1.874	.025	.049	3	3
LUAD	PARP_cleaved →	+0.410	+1.498	.029	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

ASNS by ADGRL3 expression — COAD

Explore this box plot interactively →