ADGRL3

Across TCGA cell cohorts, ADGRL3 mutation is significantly associated with the RNA expression of many other genes, with 572 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRL3-associated genes across cancer lineages are DEFB124, TCEAL6, and OR2A5. Each is linked with ADGRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRL3-to-partner and partner-to-ADGRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by ADGRL3-low versus ADGRL3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL3→partner) and Y-score (partner→ADGRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DEFB124 →	+0.137	+4.087	<.001	.009	3	2
OESOPHAGUS	TCEAL6 →	+0.051	+3.977	.001	.006	3	2
BLOOD_Myeloma	OR2A5 →	+0.040	+4.807	<.001	.006	3	2
BLOOD_Lymphoma	OR9A2 →	+0.018	+3.794	<.001	.001	3	2
LUNG_NSCLC_LUAD	TFR2 →	+0.881	+2.123	<.001	<.001	3	2
LUNG_NSCLC_LUAD	PAICS →	+0.438	+1.714	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 572 associations by consensus.

DEFB124 by ADGRL3 expression — URINARY_TRACT

Explore this box plot interactively →