ADGRL1

Across TCGA pan-cancer cohorts, ADGRL1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ADGRL1 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ADGRL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

THYM, HNSC, and KICH are the cancer types where ADGRL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	DFS	Median	II,III,IV	0.353	0.700	.007	22	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
READ	DFS	Median	III,IV	0.182	0.745	.007	12	view →
ESCA	OS	Median	II,III,IV	0.206	0.686	.004	12	view →
LUAD	OS	Median	III,IV	0.004	0.665	<.001	12	view →
UCEC	DFS	Median	All	0.934	0.826	.026	10	view →
ACC	DFS	Median	All	0.112	0.544	.042	3	view →
STAD	DFS	Median	II,III,IV	0.876	0.367	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ADGRL1–THYM (OS)

Open the THYM breakdown →