ADGRG6

Across TCGA pan-cancer cohorts, ADGRG6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ADGRG6 data layer compared with 30 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADGRG6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ADGRG6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where ADGRG6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.860	0.300	.013	18	view →
LSCC	OS	Median	III,IV	0.549	0.905	.022	4	view →
PDAC	OS	Median	II,III,IV	0.860	0.798	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ADGRG6–HNSC (DFS)

Open the HNSC breakdown →