ADGRG6

Across TCGA pan-cancer cohorts, ADGRG6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADGRG6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADGRG6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADGRG6 is over-expressed in tumor, although a few such as LUSC and LIHC show the opposite, repressed pattern.

KIRC, LUSC, and LIHC are the cancer types where ADGRG6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRG6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+1.923	<.001	11	view →
LUSC	All	II,III,IV	−1.671	<.001	7	view →
LIHC	All	All	−0.902	<.001	7	view →
HNSC	All	II,III,IV	−0.573	.006	7	view →
LUAD	Female	II,III,IV	−1.661	<.001	6	view →
BRCA	All	All	−0.415	.003	6	view →
KICH	All	All	−1.079	.006	3	view →
PAAD	All	All	+1.155	.023	2	view →
PRAD	All	All	−1.028	<.001	2	view →
KIRP	All	All	+0.674	.041	2	view →
ESCA	Female	All	+2.336	.042	1	view →
THCA	Male	III,IV	−0.847	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADGRG6–KIRC

Open the KIRC breakdown →