ADGRG6

Across TCGA patient cohorts, ADGRG6 mutation is significantly associated with the RNA expression of many other genes, with 4,477 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG6-associated genes across cancer lineages are CENPO, PCLAF, and NT5DC2. Each is linked with ADGRG6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRG6-to-partner and partner-to-ADGRG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPO grouped by ADGRG6-low versus ADGRG6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG6→partner) and Y-score (partner→ADGRG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPO →	+0.531	+1.984	<.001	<.001	3	4
UCEC	PCLAF →	+0.607	+1.469	<.001	<.001	3	4
UCEC	NT5DC2 →	+0.555	+1.554	<.001	.002	3	4
UCEC	BTBD6 →	+0.282	+1.490	.001	<.001	3	4
UCEC	WDHD1 →	+0.546	+2.080	<.001	<.001	3	4
COAD	CENPM →	+1.039	+3.332	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,477 associations by consensus.

CENPO by ADGRG6 expression — UCEC

Explore this box plot interactively →