ADGRG6

Across TCGA patient cohorts, ADGRG6 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG6-associated genes across cancer lineages are PCNA, PDCD4, and Rictor_pT1135. Each is linked with ADGRG6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRG6-to-partner and partner-to-ADGRG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADGRG6-low versus ADGRG6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG6→partner) and Y-score (partner→ADGRG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.360	+3.178	.003	.010	3	3
UCEC	PDCD4 →	-0.447	-1.273	<.001	.007	3	3
UCEC	Rictor_pT1135 →	-0.074	-1.247	.010	.041	3	3
UCEC	STAT3_pY705 →	-0.388	-1.632	<.001	<.001	3	3
UCEC	beta-Catenin →	+0.367	+2.169	.009	.002	3	3
UCEC	4E-BP1 →	+0.295	+3.247	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

PCNA by ADGRG6 expression — COAD

Explore this box plot interactively →