ADGRG6

Across TCGA cell cohorts, ADGRG6 mutation is significantly associated with the RNA expression of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRG6-associated genes across cancer lineages are PRSS54, KRTAP5-6, and OC90. Each is linked with ADGRG6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG6-to-partner and partner-to-ADGRG6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by ADGRG6-low versus ADGRG6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG6→partner) and Y-score (partner→ADGRG6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRSS54 →	+0.062	+5.452	<.001	<.001	3	1
BLOOD_Lymphoma	KRTAP5-6 →	+0.041	+4.927	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	OC90 →	+0.005	+4.357	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.636	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	MIOX →	+0.292	+3.410	<.001	.002	3	1
LARGE_INTESTINE	PHF5A →	+0.460	+3.502	.009	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

PRSS54 by ADGRG6 expression — BLOOD_Lymphoma

Explore this box plot interactively →