ADGRG5

Across TCGA patient cohorts, ADGRG5 mutation is significantly associated with the RNA expression of many other genes, with 1,297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG5-associated genes across cancer lineages are MTATP6P21, RNA5SP414, and MIR6784. Each is linked with ADGRG5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRG5-to-partner and partner-to-ADGRG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P21 grouped by ADGRG5-low versus ADGRG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG5→partner) and Y-score (partner→ADGRG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P21 →	+0.268	+2.230	<.001	.005	3	3
UCEC	RNA5SP414 →	+0.737	+2.518	<.001	.002	3	2
UCEC	MIR6784 →	+0.764	+2.669	.002	.001	3	2
STAD	MIR542 →	+0.345	+3.396	.001	.009	3	2
UCEC	LBX2 →	+0.686	+2.839	.003	.001	3	2
UCEC	DXO →	+0.383	+3.354	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,297 associations by consensus.

MTATP6P21 by ADGRG5 expression — UCEC

Explore this box plot interactively →