ADGRG4

Across TCGA patient cohorts, ADGRG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,781 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ADGRG4-associated GO terms across cancer lineages are Regulation of cell-substrate adhesion, Vacuolar transport, and Positive regulation of chemotaxis. Each is linked with ADGRG4 in more than 15 cancer types. Because this analysis shows association rather than direction, both ADGRG4-to-partner and partner-to-ADGRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate adhesion grouped by ADGRG4-low versus ADGRG4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG4→partner) and Y-score (partner→ADGRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of cell-substrate adhesion →	+0.067	+0.071	<.001	<.001	3	15
ESCA	Vacuolar transport →	+0.074	+0.160	<.001	.001	3	15
STAD	Positive regulation of chemotaxis →	+0.081	+0.086	<.001	<.001	3	14
STAD	Reactive oxygen species metabolic process →	+0.052	+0.073	<.001	<.001	3	14
SCLC	Response to alcohol →	+0.057	+0.033	.001	.004	1	16
STAD	Regulation of endothelial cell migration →	+0.055	+0.064	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,781 associations by consensus.

Regulation of cell-substrate adhesion by ADGRG4 expression — STAD

Explore this box plot interactively →