ADGRG4

Across TCGA pan-cancer cohorts, ADGRG4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ADGRG4 data layer compared with 12 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher ADGRG4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRG4 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SKCM show a favorable association.

OV, READ, and PAAD are the cancer types where ADGRG4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Quartile	All	0.710	0.869	<.001	128	view →
READ	OS	Tertile	II,III,IV	0.245	0.857	<.001	45	view →
PAAD	OS	Median	II,III,IV	0.703	0.513	.003	35	view →
SKCM	DFS	Tertile	II,III,IV	0.744	0.503	.002	30	view →
MESO	DFS	Median	II,III,IV	0.679	0.359	.016	27	view →
LGG	OS	Tertile	All	0.824	0.916	.007	23	view →
KIRC	DFS	Quartile	All	0.778	0.921	.006	22	view →
COAD	DFS	Tertile	III,IV	0.305	0.664	<.001	21	view →
STAD	OS	Tertile	III,IV	0.342	0.650	.012	21	view →
THCA	OS	Median	All	0.980	1.000	.001	19	view →
PRAD	DFS	Tertile	All	0.944	0.855	.002	16	view →
TGCT	DFS	Tertile	III,IV	0.604	1.000	.044	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ADGRG4–OV (OS)

Open the OV breakdown →