ADGRG4

Across TCGA patient cohorts, ADGRG4 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG4-associated genes across cancer lineages are ASNS, 4E-BP1_pT70, and Cyclin-B1. Each is linked with ADGRG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRG4-to-partner and partner-to-ADGRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ADGRG4-low versus ADGRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG4→partner) and Y-score (partner→ADGRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.290	+1.146	<.001	.008	3	4
COAD	4E-BP1_pT70 →	+0.152	+1.915	<.001	.009	3	4
UCEC	Cyclin-B1 →	+0.570	+1.306	<.001	<.001	3	4
BRCA	Syk →	+0.445	+2.321	.025	.037	3	4
STAD	Bim →	+0.342	+2.115	<.001	.017	3	4
STAD	C-Raf →	+0.176	+2.115	.005	.017	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

ASNS by ADGRG4 expression — UCEC

Explore this box plot interactively →