ADGRG4

Across TCGA cell cohorts, ADGRG4 mutation is significantly associated with the RNA expression of many other genes, with 1,306 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRG4-associated genes across cancer lineages are POLR1B, GDPD1, and SLC35F2. Each is linked with ADGRG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRG4-to-partner and partner-to-ADGRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR1B grouped by ADGRG4-low versus ADGRG4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG4→partner) and Y-score (partner→ADGRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POLR1B →	+0.477	+2.286	.004	<.001	3	3
LUNG_NSCLC_LUAD	GDPD1 →	+0.973	+3.358	<.001	.003	3	3
LARGE_INTESTINE	SLC35F2 →	+0.545	+1.941	.007	.009	3	3
CNS	OR2L13 →	+0.211	+2.176	<.001	.003	3	2
LIVER	SPATA31D1 →	+0.475	+4.459	.005	.001	3	2
SOFT_TISSUE	OR5B21 →	+0.120	+4.222	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,306 associations by consensus.

POLR1B by ADGRG4 expression — SKIN

Explore this box plot interactively →