ADGRG2

Across TCGA patient cohorts, ADGRG2 mutation is significantly associated with the RNA expression of many other genes, with 3,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG2-associated genes across cancer lineages are MIR4654, LINC02528, and IGHD2-2. Each is linked with ADGRG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRG2-to-partner and partner-to-ADGRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4654 grouped by ADGRG2-low versus ADGRG2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG2→partner) and Y-score (partner→ADGRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	MIR4654 →	+0.769	+5.760	<.001	.003	3	4
COAD	LINC02528 →	+0.410	+3.299	<.001	<.001	3	4
UCEC	IGHD2-2 →	+0.899	+1.473	<.001	<.001	3	3
LUSC	RN7SL97P →	+0.150	+2.814	<.001	.004	3	3
UCEC	WBP1LP2 →	+0.284	+1.480	<.001	<.001	3	3
CESC	MRPL45P1 →	+0.259	+2.924	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,962 associations by consensus.

MIR4654 by ADGRG2 expression — LGG

Explore this box plot interactively →