ADGRG2

Across TCGA pan-cancer cohorts, ADGRG2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADGRG2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ADGRG2 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRG2 is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

LUSC, KIRC, and HNSC are the cancer types where ADGRG2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRG2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−1.087	<.001	8	view →
KIRC	All	All	+0.671	<.001	8	view →
HNSC	All	II,III,IV	−0.402	.003	8	view →
LIHC	Female	All	+1.111	<.001	6	view →
BRCA	All	III,IV	−0.829	<.001	6	view →
COAD	Male	II,III,IV	−0.239	.001	4	view →
CHOL	All	All	+0.771	.017	3	view →
STAD	All	All	−0.353	.022	3	view →
THCA	All	All	+0.437	.006	2	view →
ESCA	All	All	−0.713	.029	1	view →
KICH	Male	III,IV	−0.452	.011	1	view →
LUAD	Female	II,III,IV	−0.410	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADGRG2–LUSC

Open the LUSC breakdown →