ADGRG2

Across TCGA patient cohorts, ADGRG2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG2-associated genes across cancer lineages are Stathmin, Mre11, and ATM. Each is linked with ADGRG2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRG2-to-partner and partner-to-ADGRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by ADGRG2-low versus ADGRG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG2→partner) and Y-score (partner→ADGRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Stathmin →	+0.187	+2.334	.003	.018	3	5
LUSC	Mre11 →	+0.189	+2.834	.001	.034	2	4
COAD	ATM →	-0.502	-3.169	.002	.017	3	3
COAD	TAZ →	+0.244	+3.195	.003	.009	3	3
COAD	53BP1 →	-0.696	-3.000	<.001	.035	3	3
COAD	E-Cadherin →	-1.074	-3.691	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Stathmin by ADGRG2 expression — COAD

Explore this box plot interactively →