ADGRG2

Across TCGA cell cohorts, ADGRG2 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ADGRG2-associated genes across cancer lineages are PRY, OBP2B, and KRT40. Each is linked with ADGRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG2-to-partner and partner-to-ADGRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRY grouped by ADGRG2-low versus ADGRG2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG2→partner) and Y-score (partner→ADGRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRY →	+0.017	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	OBP2B →	+0.049	+3.714	.001	.006	3	1
BLOOD_Lymphoma	KRT40 →	+0.394	+4.070	<.001	.004	3	1
LARGE_INTESTINE	PNMA6F →	+0.004	+4.415	<.001	.007	3	1
BLOOD_Leukemia	CRISP1 →	+0.121	+5.201	.003	.006	3	1
LUNG_SCLC	OR9G4 →	+0.112	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRY by ADGRG2 expression — BLOOD_Lymphoma

Explore this box plot interactively →