Across TCGA pan-cancer cohorts, ADGRF5-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ADGRF5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ADGRF5-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRF5-AS1 is over-expressed in tumor, although a few such as LUSC and KIRP show the opposite, repressed pattern.

LUSC, KIRP, and BRCA are the cancer types where ADGRF5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRF5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	−0.241	<.001	6	view →
KIRP	Male	All	−0.039	.001	5	view →
BRCA	All	III,IV	−0.057	.013	2	view →
STAD	Male	All	+0.037	.015	2	view →
LIHC	All	All	+0.009	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ADGRF5-AS1 RNA expression & survival · all ADGRF5-AS1 data types