ADGRF4

Across TCGA patient cohorts, ADGRF4 mutation is significantly associated with the RNA expression of many other genes, with 4,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF4-associated genes across cancer lineages are C18orf54, ZNF77, and CENPQ. Each is linked with ADGRF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRF4-to-partner and partner-to-ADGRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf54 grouped by ADGRF4-low versus ADGRF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF4→partner) and Y-score (partner→ADGRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf54 →	+0.712	+2.523	<.001	<.001	3	3
UCEC	ZNF77 →	+0.426	+2.818	<.001	.001	3	3
UCEC	CENPQ →	+0.505	+3.595	.005	.001	3	3
UCEC	USP36 →	+0.334	+2.137	.002	.001	3	3
HNSC	RNASE12 →	+0.065	+6.132	<.001	.001	3	3
HNSC	LINC02304 →	+0.172	+4.505	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,600 associations by consensus.

C18orf54 by ADGRF4 expression — UCEC

Explore this box plot interactively →