ADGRF4

Across TCGA pan-cancer cohorts, ADGRF4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADGRF4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ADGRF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADGRF4 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

LUAD, LUSC, and THCA are the cancer types where ADGRF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+2.823	<.001	9	view →
LUSC	Male	All	+2.766	<.001	8	view →
THCA	Male	All	+1.074	<.001	8	view →
BLCA	All	IV	+2.699	.005	6	view →
HNSC	Female	III,IV	+1.568	.003	6	view →
BRCA	Female	II,III,IV	+0.728	<.001	6	view →
KIRC	Male	All	+0.536	.001	6	view →
KICH	All	All	−0.479	<.001	5	view →
KIRP	All	III,IV	+0.642	.021	4	view →
CHOL	All	All	+1.184	.009	2	view →
PRAD	All	All	−0.176	.022	2	view →
COAD	Male	All	+0.677	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADGRF4–LUAD

Open the LUAD breakdown →