ADGRF4

Across TCGA patient cohorts, ADGRF4 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF4-associated genes across cancer lineages are eIF4E, c-Met_pY1235, and CD20. Each is linked with ADGRF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRF4-to-partner and partner-to-ADGRF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ADGRF4-low versus ADGRF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF4→partner) and Y-score (partner→ADGRF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.200	+3.183	.011	.009	3	3
UCEC	c-Met_pY1235 →	+0.058	+1.817	.036	.015	3	3
LUAD	CD20 →	+0.175	+3.016	.030	.018	3	2
SKCM	eEF2 →	+0.280	+1.247	.012	.043	3	2
UCEC	MEK1 →	+0.438	+2.662	.001	<.001	3	2
SKCM	N-Cadherin →	+0.133	+1.807	.044	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

eIF4E by ADGRF4 expression — UCEC

Explore this box plot interactively →