ADGRF1

Across TCGA patient cohorts, ADGRF1 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF1-associated genes across cancer lineages are PKC-b-II_pS660, RAD51, and ATM. Each is linked with ADGRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRF1-to-partner and partner-to-ADGRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by ADGRF1-low versus ADGRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF1→partner) and Y-score (partner→ADGRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.188	-1.514	.046	.015	3	3
UCEC	RAD51 →	+0.136	+2.415	.004	.003	3	3
UCEC	ATM →	-0.541	-2.687	<.001	.005	3	3
UCEC	EGFR →	-0.181	-3.674	<.001	.001	3	2
COAD	eIF4E →	+0.238	+2.832	.015	.035	3	2
UCEC	FoxM1 →	+0.314	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

PKC-b-II_pS660 by ADGRF1 expression — UCEC

Explore this box plot interactively →