ADGRF1

Across TCGA pan-cancer cohorts, ADGRF1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ADGRF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADGRF1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRF1 is over-expressed in tumor, although a few such as KIRC and HNSC show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where ADGRF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−4.430	<.001	12	view →
HNSC	All	III,IV	−1.598	<.001	11	view →
KICH	All	II,III,IV	−2.197	<.001	10	view →
KIRP	All	All	−1.795	<.001	7	view →
LUAD	Female	II,III,IV	+2.444	<.001	6	view →
PAAD	All	All	+2.375	.036	4	view →
LUSC	Male	II,III,IV	−1.386	<.001	4	view →
BRCA	Female	II,III,IV	−0.319	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ADGRF1–KIRC

Open the KIRC breakdown →