ADGRE2

Across TCGA cell cohorts, ADGRE2 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRE2-associated genes across cancer lineages are OPRPN, IFNA2, and CABS1. Each is linked with ADGRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRE2-to-partner and partner-to-ADGRE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPRPN grouped by ADGRE2-low versus ADGRE2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE2→partner) and Y-score (partner→ADGRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OPRPN →	+0.139	+5.029	<.001	.006	3	2
OVARY	IFNA2 →	+0.012	+4.222	<.001	.006	3	2
SKIN	CABS1 →	+0.034	+4.415	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR1L3 →	+0.028	+4.887	<.001	.009	3	2
BLOOD_Myeloma	USP17L4 →	+0.040	+4.807	<.001	.006	3	1
LUNG_SCLC	OR8B12 →	+0.036	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

OPRPN by ADGRE2 expression — LUNG_SCLC

Explore this box plot interactively →