ADGRE2

Across TCGA pan-cancer cohorts, ADGRE2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ADGRE2 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ADGRE2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRE2 expression acts as an unfavorable survival marker, although some lineages such as UCS and UVM show a favorable association.

LGG, KIRP, and BLCA are the cancer types where ADGRE2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.732	0.890	<.001	54	view →
KIRP	DFS	Median	All	0.782	1.000	.001	44	view →
BLCA	DFS	Quartile	II,III,IV	0.436	0.563	.015	24	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	24	view →
STAD	OS	Tertile	III,IV	0.291	0.647	.003	18	view →
LIHC	OS	Tertile	All	0.542	0.712	.017	15	view →
HNSC	OS	Quartile	III,IV	0.307	0.590	.008	14	view →
UVM	OS	Median	All	0.925	0.707	.009	10	view →
LUSC	DFS	Median	II,III,IV	0.600	0.871	.011	10	view →
ACC	DFS	Tertile	II,III,IV	0.332	0.761	.014	8	view →
ESCA	DFS	Tertile	III,IV	0.507	0.247	.025	5	view →
THCA	OS	Median	IV	0.599	1.000	.004	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ADGRE2–LGG (OS)

Open the LGG breakdown →