ADGRE1

Across TCGA cell cohorts, ADGRE1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ADGRE1-associated genes across cancer lineages are FAM205C, RAB3C, and VSTM2A. Each is linked with ADGRE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRE1-to-partner and partner-to-ADGRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM205C grouped by ADGRE1-low versus ADGRE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE1→partner) and Y-score (partner→ADGRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM205C →	+0.008	+3.700	<.001	.009	3	2
OVARY	RAB3C →	+1.120	+3.584	<.001	.006	3	1
OVARY	VSTM2A →	+0.107	+3.710	<.001	.008	3	1
OVARY	PNLIP →	+0.019	+3.405	.002	.005	3	1
OVARY	DMRTC1B →	+0.270	+4.184	<.001	.001	3	1
OVARY	OR2T4 →	+0.016	+3.807	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

FAM205C by ADGRE1 expression — LARGE_INTESTINE

Explore this box plot interactively →