ADGRB3

Across TCGA patient cohorts, ADGRB3 mutation is significantly associated with the RNA expression of many other genes, with 7,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRB3-associated genes across cancer lineages are MIS18A, SF3B6, and MCM10. Each is linked with ADGRB3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ADGRB3-to-partner and partner-to-ADGRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIS18A grouped by ADGRB3-low versus ADGRB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB3→partner) and Y-score (partner→ADGRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MIS18A →	+0.597	+2.700	<.001	<.001	3	7
LUAD	SF3B6 →	+0.254	+1.227	<.001	.003	3	7
STAD	MCM10 →	+0.679	+2.700	<.001	<.001	3	7
STAD	MTIF2 →	+0.430	+3.186	<.001	<.001	3	7
STAD	FAM136A →	+0.355	+2.448	.001	.001	2	7
UCEC	OIP5 →	+0.674	+1.828	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,766 associations by consensus.

MIS18A by ADGRB3 expression — STAD

Explore this box plot interactively →