ADGRB3

Across TCGA pan-cancer cohorts, ADGRB3 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ADGRB3 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ADGRB3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ADGRB3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

KIRC, PAAD, and LGG are the cancer types where ADGRB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.840	0.661	.002	56	view →
PAAD	OS	Tertile	All	0.544	0.270	<.001	52	view →
LGG	DFS	Median	All	0.491	0.277	<.001	49	view →
LUAD	OS	Quartile	All	0.772	0.603	.001	37	view →
CESC	DFS	Median	II,III,IV	0.316	0.608	.004	30	view →
ACC	DFS	Quartile	All	0.145	0.598	.006	22	view →
UCEC	OS	Median	All	0.834	0.903	.004	22	view →
LUSC	OS	Tertile	III,IV	0.511	0.797	.009	21	view →
BRCA	OS	Tertile	III,IV	0.955	0.841	.012	18	view →
STAD	DFS	Median	All	0.602	0.806	.004	18	view →
BLCA	OS	Median	All	0.467	0.687	.007	14	view →
GBM	OS	Quartile	All	0.568	0.219	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ADGRB3–KIRC (DFS)

Open the KIRC breakdown →