ADGRB3

Across TCGA patient cohorts, ADGRB3 mutation is significantly associated with the total protein of many other genes, with 95 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRB3-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and eIF4E. Each is linked with ADGRB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRB3-to-partner and partner-to-ADGRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ADGRB3-low versus ADGRB3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB3→partner) and Y-score (partner→ADGRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.345	+3.000	<.001	<.001	3	5
COAD	Cyclin-B1 →	+0.598	+2.593	.001	<.001	3	5
UCEC	eIF4E →	+0.174	+1.378	<.001	<.001	3	4
COAD	FASN →	+0.415	+1.686	.002	.013	3	4
COAD	FoxM1 →	+0.285	+1.887	.020	.029	3	4
STAD	TFRC →	+0.633	+3.700	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

4E-BP1 by ADGRB3 expression — STAD

Explore this box plot interactively →