ADGRB3

Across TCGA cell cohorts, ADGRB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,889 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADGRB3-associated GO terms across cancer lineages are Positive regulation of circadian sleep/wake cycle, wakefulness, Regulation of telomerase RNA localization to Cajal body, and Gamma-aminobutyric acid signaling pathway. Each is linked with ADGRB3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ADGRB3-to-partner and partner-to-ADGRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of circadian sleep/wake cycle, wakefulness grouped by ADGRB3-low versus ADGRB3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB3→partner) and Y-score (partner→ADGRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of circadian sleep/wake cycle, wakefulness →	+0.995	+1.295	.003	.004	3	7
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.119	+1.296	.002	<.001	3	7
SOFT_TISSUE	Gamma-aminobutyric acid signaling pathway →	-0.226	-0.858	<.001	<.001	3	6
BONE	Negative regulation of T-helper 1 type immune response →	-1.468	-1.637	<.001	<.001	3	6
BONE	Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell →	-1.474	-1.316	<.001	<.001	3	6
URINARY_TRACT	Cerebral cortex tangential migration →	+1.123	+0.363	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

Positive regulation of circadian sleep/wake cycle, wakefulness by ADGRB3 expression — SOFT_TISSUE

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