ADGRB3

Across TCGA cell cohorts, ADGRB3 mutation is significantly associated with the RNA expression of many other genes, with 840 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRB3-associated genes across cancer lineages are C18orf21, SCGB3A2, and HINT1. Each is linked with ADGRB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRB3-to-partner and partner-to-ADGRB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf21 grouped by ADGRB3-low versus ADGRB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB3→partner) and Y-score (partner→ADGRB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C18orf21 →	+0.520	+1.764	.002	.005	3	3
LUNG_NSCLC_LUAD	SCGB3A2 →	+0.260	+1.807	.004	.004	3	3
SKIN	HINT1 →	+0.388	+2.386	.007	.007	3	3
UPPER_AERODIGESTIVE_TRACT	TAS2R9 →	+0.049	+4.870	<.001	.001	3	2
PANCREAS	PIWIL3 →	+0.016	+4.011	<.001	.009	3	2
KIDNEY	CLEC2A →	+0.046	+5.000	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 840 associations by consensus.

C18orf21 by ADGRB3 expression — LARGE_INTESTINE

Explore this box plot interactively →